Polzastobart, CAS 2640981-19-5

Product Description: Polzastobart (JTX-8064) is a humanized IgG4 monoclonal antagonist antibody that selectively binds LILRB2 and prevents it from binding its ligands, classical and non-classical MHC I molecules. Polzastobart enhances pro-inflammatory cytokine production in macrophages by blocking the ability of LILRB2 to bind HLA-A/B and/or HLA-G, a marker of immunotolerance on cancer cells. Polzastobart is a macrophage immune checkpoint inhibitor[1].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Kyriakos P. Papadopoulos, et al. Phase 1, first-in-human trial of JTX-8064, an anti-LILRB2/ILT4 monoclonal antibody, as monotherapy and in combination with anti-PD-1 in adult patients with advanced solid tumors (INNATE).

CAS Number: 2640981-19-5

Molecular Weight: N/A

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Others

• Artikelnummer: MEXHY-P990061-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P990061-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK