Product Description: Ponsegromab (PF 06946860) is a potent and selective humanized anti-GDF15 antibody inhibitor with anti-cachexia activity. Ponsegromab binds to GDF15 and prevents the binding of GDF15 to GFRAL, thereby blocking GDF15/GFRAL-mediated signaling. Ponsegromab can be used in the research of cancers[1].
Applications: Cancer-Kinase/protease
Formula: N/A
References: [1]E.J. Roeland, et al. 1696TiP Phase Ib study to assess the effect of PF-06946860 on appetite following subcutaneous administration in patients with anorexia and advanced cancer. VOLUME 32, SUPPLEMENT 5, S1185, SEPTEMBER 01, 2021. Annals of oncology.
CAS Number: 2368950-15-4
Molecular Weight: N/A
Compound Purity: 96.11
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: TGF-beta/Smad