Toralizumab, CAS 252662-47-8

Product Description: Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research[1][2].

Applications: COVID-19-immunoregulation

Formula: N/A

References: [1]Camilo E Fadul, et al. Safety and Immune Effects of Blocking CD40 Ligand in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 2021 Oct 15;8(6):e1096./[2]Kenneth C Kalunian, et al. Treatment of systemic lupus erythematosus by inhibition of T cell costimulation with anti-CD154: a randomized, double-blind, placebo-controlled trial. Arthritis Rheum. 2002 Dec;46(12):3251-8.

CAS Number: 252662-47-8

Molecular Weight: 148.43 (kD)

Compound Purity: 95.00

Research Area: Inflammation/Immunology

Solubility: H2O

Target: TNF Receptor

• Artikelnummer: MEXHY-P99325-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-P99325-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK