Product Description: TSR-033 is a high affinity human IgG4 antibody targeting LAG-3 (lymphocyte activation gene-3), a co-receptor associated with impaired T cell function and often co-expressed with PD-1, that enhances T cell function and PD-1 blocking activity in vitro and in vivo. TSR-033 has anti-tumor activity[1].
Applications: Cancer-programmed cell death
Formula: N/A
References: [1]Srimoyee Ghosh, et al. TSR-033, a Novel Therapeutic Antibody Targeting LAG-3, Enhances T-Cell Function and the Activity of PD-1 Blockade In Vitro and In Vivo. Mol Cancer Ther. 2019 Mar;18(3):632-641.
CAS Number: 2225940-96-3
Molecular Weight: N/A
Compound Purity: 95.25
Research Area: Cancer
Solubility: 10 mM in DMSO
Target: LAG-3