Human ApoE4 protein

Human ApoE4 protein
Artikelnummer
GTX136908-PRO-500
Verpackungseinheit
500 μg
Hersteller
GeneTex

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Species: Human

Product Description: APOE belongs to the apolipoprotein family and is a 299 a.a. protein with three allelic variants that give rise to the APOE 2, APOE 3, and APOE 4 isoforms. APOE is directly involved in lipoprotein metabolism and functions as a ligand for multiple receptors (e.g., the LDL receptor). These isoforms are critical for brain homeostasis and, while APOE 2 was shown to be protective in terms of Alzheimer’s disease (AD) risk, the 34.4 kDa APOE 4 isoform is a major risk factor for late-onset AD.

Form: Lyophilized powder

Buffer (with preservative): Reconstitute with distilled water to 0.1 mg/ml. Lyophilized from 50mM PBS, 100mM NaCl, 5% Trehalose, no Preservative.

Concentration:

Background: The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

Uniprot ID: P02649

Region Sequence: Full-length human ApoE4 protein (NP_000032.1)

ExpressionSystem: E. Coli

Conjugation: Unconjugated

Full Name: apolipoprotein E
Mehr Informationen
Artikelnummer GTX136908-PRO-500
Hersteller GeneTex
Hersteller Artikelnummer GTX136908-PRO-500
Verpackungseinheit 500 μg
Mengeneinheit STK
Human Gene ID 348
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