LPA1 Blocking Peptide

Formulation: 200 µg of blocking peptide lyophilized from TBS, pH 7.4

Shelf life (days): 1095

Notes: To be used in conjunction with Cayman’s LPA1 polyclonal antibody (Catalog No. 10005280) to block protein-antibody complex formation during immunochemical analysis of LPA1. · LPA1 (also known as EDG-2) is one of four known LPA receptors (LPA1-4).{13001} LPA1-3 are part a family of G protein-coupled receptors that share identity to the sphingosine-1-phosphate receptors (S1P1-5).{11049} LPA1 couples with three types of G proteins, Gi/o, Gq, and G12/13 to induce a range of cellular responses including activation of phospholipase C, multiple kinases, the serum response element, and cell proliferation.{11808,12477} LPA1 mRNA is detected in a wide range of tissues and cells including brain, heart, small intestine, spleen, testis, kidney, HeLa cells, and A549 cells.{11810,12912} Murine and human LPA1 have 364 amino acids with an estimated molecular weight of 41 kDa.{12477} Cayman’s LPA1 polyclonal antibody detects the protein from several species at 43-50 kDa, suggesting heterogeneous LPA1 post-translational modifications in distinct cells.

• Artikelnummer: CAY10006984
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 10006984-1
• Verpackungseinheit: 1 Piece
• Mengeneinheit: STK
• Methode: Western Blotting, Immunocytochemistry