PELI2 Blocking Peptide (N terminal)

Description of Target: PELI2 is a E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. It is involved in the TLR and IL-1 signaling pathways via interaction with the complex containing IRAK kinases and TRAF6. It mediates IL1B-induced IRAK1 'Lys-63'-linked polyubiquitination and possibly 'Lys-48'-linked ubiquitination. It may be important for LPS- and IL1B-induced MAP3K7- dependent, but not MAP3K3-dependent, NF-kappa-B activation. And it can activate the MAP (mitogen activated protein) kinase pathway leading to activation of ELK1.

Product Format: Lyophilized powder

Protein Size: 420

• Artikelnummer: AVIAAP48876-100
• Hersteller: Aviva Systems Biology
• Hersteller Artikelnummer: AAP48876-100UG
• Verpackungseinheit: 100µg
• Mengeneinheit: STK
• Methode: Western Blotting
• Human Gene ID: 57161