PSEN1 Blocking peptide (Middle region)

Description of Target: Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined.

Product Format: Lyophilized powder

Protein Size: 467

• Artikelnummer: AVIAAP96893-100
• Hersteller: Aviva Systems Biology
• Hersteller Artikelnummer: AAP96893-100UG
• Verpackungseinheit: 100µg
• Mengeneinheit: STK
• Methode: Western Blotting
• Human Gene ID: 5663