Conjugation: HRP: Horseradish Peroxidase
Description of Target: TRIB2 is one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia.
Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TRIB2
Key Reference: Lin,K.R., (2007) J. Biol. Chem. 282 (30), 21962-21972
Molecular Weight: 39kDa
Peptide Sequence: Synthetic peptide located within the following region:
YPFHDIEPSSLFSKIRRGQFNIPETLSPKAKCLIRSILRREPSERLTSQEProduct Format: Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.
Protein Name: Tribbles homolog 2
Protein Size: 343
Purification: Affinity Purified