Tal1(BTL73), 0.2mg/mL

Description: Activation of TAL1 characterizes up to 60% of cases of human T cell acute lymphoblastic leukemia, making it the most frequent gain-of-function mutation observed in this disorder. TAL1 (also designated SCL) is a serine phosphoprotein and basic helix-loop-helix transcription factor known to regulate embryonic hematopoiesis. This transcription factor binds as a heterodimer with E2A and HEB/HTF4 to a nucleotide sequence motif termed the E-box. In addition, leukemogenesis is accelerated dramatically by transgenic co-expression of TAL1 and the catalytic subunit of casein kinase IIHLH transcription factors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Conjugate: Purified, with BSA

Concentration: 0.2 mg/mL

Storage buffer: PBS, 0.05% BSA, 0.05% azide

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Clone: BTL73

Entrez Gene ID: 6886

Immunogen: Recombinant human full-length TAL1 protein

Expected AB Applications: IHC (published for clone)/ChiP (published for clone)/EMSA (published for clone)/Flow (intracellular) (published for clone)/IHC (FFPE) (published for clone)

Z-Antibody Applications: CHiP (published)/Flow, intracellular (published)/IHC (published)/IHC, FFPE (published)/EMSA (published)

• Artikelnummer: BTMBNUB2852-500
• Hersteller: Biotium
• Hersteller Artikelnummer: BNUB2852-500
• Verpackungseinheit: 500 uL
• Mengeneinheit: STK
• Reaktivität: Human
• Klonalität: Monoclonal
• Methode: Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP), EMSA
• Isotyp: IgG1 kappa
• Wirt: Mouse