11-Ketodihydrotestosterone-d3, CAS 2479914-02-6

Product Description: 11-Ketodihydrotestosterone-d3 is the deuterium labeled 11-Ketodihydrotestosterone. 11-Ketodihydrotestosterone (11-KDHT; 5α-Dihydro-11-keto testosterone) is an endogenous steroid and a metabolite of 11β-Hydroxyandrostenedione. 11-Ketodihydrotestosterone is an active androgen and is also a potent androgen receptor (AR) agonist with a Ki of 20.4 nM and an EC50 of 1.35 nM for human AR. 11-Ketodihydrotestosterone drives gene regulation, protein expression and cell growth in androgen-dependent prostate cancer cells[1][2].

Formula: C19H25D3O3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Pretorius E, et al. 1-Ketotestosterone and 11-Ketodihydrotestosterone in Castration Resistant Prostate Cancer: Potent Androgens Which Can No Longer Be Ignored. PLoS One. 2016 Jul 21;11(7):e0159867./[3]du Toit T, et al. Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone and 11keto-dihydrotestosterone. J Steroid Biochem Mol Biol. 2017 Feb;166:54-67.

CAS Number: 2479914-02-6

Molecular Weight: 307.44

Compound Purity: 99.00

Research Area: Endocrinology

Solubility: DMSO : 100 mg/mL (ultrasonic;warming)

Target: Androgen Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-135794S-500UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-135794S-500UG
• Verpackungseinheit: 500 μg
• Mengeneinheit: STK