5-Aminosalicylic acid-d3 (disodium)

Product Description: 5-Aminosalicylic acid-d3 disodium is deuterated labeled 5-Aminosalicylic Acid (HY-15027). 5-Aminosalicylic acid (Mesalamine) acts as a specific PPARγ agonist and also inhibits p21-activated kinase 1 (PAK1) and NF-κB.5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).

Applications: COVID-19-anti-virus

Formula: C7H2D3NNa2O3

References: [1]Dammann K, et al. PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation. Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60./[2]Ramadan A, et al. Mesalazine, an osteopontin inhibitor: The potential prophylactic and remedial roles in induced liver fibrosis in rats. Chem Biol Interact. 2018 Jun 1;289:109-118. /[3]Fang HM, et al. 5-aminosalicylic acid in combination with Nimesulide inhibits proliferation of colon carcinoma cells in vitro. World J Gastroenterol. 2007 May 28;13(20):2872-7./[4]Rousseaux C, et al. The 5-aminosalicylic acid antineoplastic effect in the intestine is mediated by PPARγ. Carcinogenesis. 2013 Nov;34(11):2580-6./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 200.12

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Isotope-Labeled Compounds;NF-κB;PAK;PPAR

• Artikelnummer: MEXHY-15027S3-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15027S3-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK