α-Lipoic Acid-d5, CAS 1189471-66-6

Product Description: α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

Formula: C8H9D5O2S2

References: [1]Xiao L, et al. Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. Biofactors. 2006;27(1-4):157-65.;Yang Y, et al. Alpha-lipoic acid improves high-fat diet-induced hepatic steatosis by modulating the transcription factors SREBP-1, FoxO1 and Nrf2 via the SIRT1/LKB1/AMPK pathway. J Nutr Biochem. 2014 Nov;25(11):1207-1217.;Lei D, et al. Synergistic neuroprotective effect of rasagiline and idebenone against retinal ischemia-reperfusion injury via the Lin28-let-7-Dicer pathway. Oncotarget. 2018 Jan 30;9(15):12137-12153.;Pibiri M, et al. α-Lipoic acid induces Endoplasmic Reticulum stress-mediated apoptosis in hepatoma cells. Sci Rep. 2020 Apr 28;10(1):7139./[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1189471-66-6

Molecular Weight: 211.36

Compound Purity: 96.68

Research Area: Cancer; Infection; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Apoptosis;Endogenous Metabolite;HIV;Isotope-Labeled Compounds;Mitochondrial Metabolism;NF-κB

• Artikelnummer: MEXHY-N0492S-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0492S-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK