AGN 193109-d7, CAS 1216429-25-2

Product Description: AGN 193109-d7 is the deuterium labeled AGN 193109. AGN 193109 is a retinoid analog, and acts as a specific and highly effective antagonist of retinoic acid receptors (RARs), with Kds of 2 nM, 2 nM, and 3 nM for RARα, RARβ, and RARγ, respectively.

Formula: C28H17D7O2

References: [1]Johnson AT, et al. Synthesis and characterization of a highly potent and effective antagonist of retinoic acid receptors. J Med Chem. 1995 Nov 24;38(24):4764-7./[2]Agarwal C, et al. AGN193109 is a highly effective antagonist of retinoid action in human ectocervical epithelial cells. J Biol Chem. 1996 May 24;271(21):12209-12./[3]Standeven AM, et al. Specific antagonist of retinoid toxicity in mice. Toxicol Appl Pharmacol. 1996 May;138(1):169-75./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1216429-25-2

Molecular Weight: 399.53

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Autophagy;Isotope-Labeled Compounds;RAR/RXR

• Artikelnummer: MEXHY-U00449S-10
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-U00449S-10
• Green Labware: Nein
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK