Ambroxol-d5 (hydrochloride), CAS 2741380-71-0

Product Description: Ambroxol-d5 (hydrochloride) is the deuterium labeled Ambroxol hydrochloride. Ambroxol hydrochloride (NA-872 hydrochloride), an active metabolite of the proagent Bromhexine, has potent expectorant effects. Ambroxol hydrochloride is a glucocerebrosidase (GCase) chaperone and increases glucocerebrosidase activity. Ambroxol hydrochloride induces lung autophagy and has the potential for Parkinson disease and neuronopathic Gaucher disease research[1][2].

Formula: C13H14D5Br2ClN2O

References: [1]Vojo Deretic, et al. Enhancement of lung levels of antibiotics by ambroxol and bromhexine. Expert Opin Drug Metab Toxicol. 2019 Mar;15(3):213-218./[2]Anna Migdalska-Richards, et al. Ambroxol effects in glucocerebrosidase and α-synuclein transgenic mice. Ann Neurol. 2016 Nov;80(5):766-775./[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 2741380-71-0

Molecular Weight: 419.59

Compound Purity: 99.46

Research Area: Metabolic Disease; Neurological Disease

Solubility: 10 mM in DMSO

Target: Autophagy;Glucosidase;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B1039AS-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1039AS-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK