Amlodipine-1,1,2,2-d4 (maleate), CAS 1185246-15-4

Product Description: Amlodipine-1,1,2,2-d4 (maleate) is the deuterium labeled Amlodipine. Amlodipine, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine can be used for the research of high blood pressure and cancer[1][2][3].

Formula: C24H25D4ClN2O9

References: [1]Kishen G. Bulsara, et al. Amlodipine./[2]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586./[3]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12./[4]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1185246-15-4

Molecular Weight: 528.97

Compound Purity: 98.04

Research Area: Cancer; Cardiovascular Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Calcium Channel;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0317S-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0317S-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK