Amlodipine-d9 (maleate)

Product Description: Amlodipine-d9 maleate is deuterated labeled Amlodipine maleate (HY-B0317A). Amlodipine maleate is a dihydropyridine calcium channel blocker, acts as an orally active antianginal agent. Amlodipine maleate blocks the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine maleate can be used for the research of high blood pressure and cancer[1][2][3].

Applications: Neuroscience-Neuromodulation

Formula: C24H20D9ClN2O9

References: [1]Yoshida J, et, al. Antitumor effects of amlodipine, a Ca2+ channel blocker, on human epidermoid carcinoma A431 cells in vitro and in vivo. Eur J Pharmacol. 2004 May 25;492(2-3):103-12./[2]Okuyama Y, et, al. The effects of anti-hypertensive drugs and the mechanism of hypertension in vascular smooth muscle cell-specific ATP2B1 knockout mice. Hypertens Res. 2018 Feb;41(2):80-87./[3]Kishen G. Bulsara, et al. Amlodipine./[4]Haria M, et al. Amlodipine. A reappraisal of its pharmacological properties and therapeutic use in cardiovascular disease [published correction appears in Drugs 1995 Nov;50(5):896]. Drugs. 1995;50(3):560-586./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 534.00

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Calcium Channel;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0317AS1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0317AS1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK