Amodiaquine-d10 (hydrochloride)

Product Description: Amodiaquine-d10 hydrochloride is deuterated labeled Amodiaquine (HY-B1322A). Amodiaquine (Amodiaquin), a 4-aminoquinoline class of antimalarial agent, is a potent and orally active histamine N-methyltransferase inhibitor. Amodiaquine is also a Nurr1 agonist and specifically binds to Nurr1-LBD (ligand binding domain) with an EC50 of ~20 μM. Anti-inflammatory effect[1][2][3][4].

Applications: COVID-19-immunoregulation

Formula: C20H14D10Cl3N3O

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Chun-Hyung Kim, et al. Nuclear receptor Nurr1 agonists enhance its dual functions and improve behavioral deficits in an animal model of Parkinson's disease. Proc Natl Acad Sci U S A. 2015 Jul 14;112(28):8756-61./[3]Keita Kinoshita, et al. A Nurr1 agonist amodiaquine attenuates inflammatory events and neurological deficits in a mouse model of intracerebral hemorrhage. J Neuroimmunol. 2019 May 15;330:48-54./[4]Akira Yokoyama, et al. Effect of amodiaquine, a histamine N-methyltransferase inhibitor, on, Propionibacterium acnes and lipopolysaccharide-induced hepatitis in mice. Eur J Pharmacol. 2007 Mar 8;558(1-3):179-84./[5]M T HOEKENGA. The treatment of acute malaria with single oral doses of amodiaquin, chloroquine, hydroxychloroquine and pyrimethamine. Am J Trop Med Hyg. 1954 Sep;3(5):833-8.

Molecular Weight: 438.84

Research Area: Infection; Inflammation/Immunology; Neurological Disease

Solubility: 10 mM in DMSO

Target: Histone Methyltransferase;Isotope-Labeled Compounds;Nuclear Hormone Receptor 4A/NR4A;Parasite

• Artikelnummer: MEXHY-B1322AS1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1322AS1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK