Apalutamide-13C,d3

Product Description: Apalutamide-13C,d3 is the 13C- and deuterium labeled Apalutamide. Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

Applications: Cancer-programmed cell death

Formula: C20 13CH12D3F4N5O2S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223./[2]Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72(6):1494-503./[3]Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133

Molecular Weight: 481.45

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Androgen Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-16060S2-500UG
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16060S2-500UG
• Verpackungseinheit: 500 μg
• Mengeneinheit: STK