Apalutamide-d7

Product Description: Apalutamide-d7 is deuterated labeled Apalutamide (HY-16060). Apalutamide (ARN-509) is a potent and competitive androgen receptor (AR) antagonist, binding AR with an IC50 of 16 nM[1].

Applications: Cancer-programmed cell death

Formula: C21H8D7F4N5O2S

References: [1]Clegg NJ, et al. ARN-509: a novel antiandrogen for prostate cancer treatment. Cancer Res. 2012 Mar 15;72(6):1494-503./[2]Smith MR, et al. Phase 2 Study of the Safety and Antitumor Activity of Apalutamide (ARN-509), a Potent Androgen Receptor Antagonist, in the High-risk Nonmetastatic Castration-resistant Prostate Cancer Cohort. Eur Urol. 2016 May 6. pii: S0302-2838(16)30133/[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 484.48

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Androgen Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-16060S3-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-16060S3-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK