Arbutin-d4

Product Description: Arbutin-d4 is deuterium labeled Arbutin. Arbutin (β-Arbutin) is a competitive inhibitor of tyrosinase in melanocytes, with Kiapp values of 1.42 mM for monophenolase; 0.9 mM for diphenolase. Arbutin is also used as depigmenting agents[1]. Arbutin is a natural polyphenol isolated from the bearberry plant Arctostaphylos uvaursi, possesses with anti-oxidant, anti-inflammatory and anti-tumor properties[2][3].

Applications: Cancer-programmed cell death

Formula: C12H12D4O7

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Jiang L, et al. Investigation of the pro-apoptotic effects of arbutin and its acetylated derivative on murinemelanoma cells. Int J Mol Med. 2018 Feb;41(2):1048-1054./[3]Nalban N, et al. Arbutin Attenuates Isoproterenol-Induced Cardiac Hypertrophy by Inhibiting TLR-4/NF-κB Pathway in Mice. Cardiovasc Toxicol. 2019 Sep 4./[4]Garcia-Jimenez A, et al. Action of tyrosinase on alpha and beta-arbutin: A kinetic study. PLoS One. 2017 May 11;12(5):e0177330.

Molecular Weight: 276.28

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Isotope-Labeled Compounds;Tyrosinase

• Artikelnummer: MEXHY-N0192S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0192S-1
• Green Labware: Nein
• Verpackungseinheit: 1mg
• Mengeneinheit: STK