Brexpiprazole-d8-1, CAS 1427049-19-1

Product Description: Brexpiprazole-d8-1 is the deuterium labeled Brexpiprazole[1]. Brexpiprazole (OPC-34712), an atypical orally active antipsychotic agent, is a partial agonist of human 5-HT1A and dopamine D2L receptor with Kis of 0.12 nM and 0.3 nM, respectively. Brexpiprazole is also a 5-HT2A receptor antagonist with a Ki of 0.47 nM. Brexpiprazole also shows potent antagonist activity at human noradrenergic α1B (Ki=0.17 nM) and α2C receptors (Ki=0.59 nM)[2][3].

Applications: Neuroscience-Neuromodulation

Formula: C25H19D8N3O2S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Ishima T, et al. Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors. Eur Neuropsychopharmacol. 2015 Apr;25(4):505-11./[3]Yoshimi N, et al. Improvement of dizocilpine-induced social recognition deficits in mice by brexpiprazole, a novel serotonin-dopamine activity modulator. Eur Neuropsychopharmacol. 2015 Mar;25(3):356-64.

CAS Number: 1427049-19-1

Molecular Weight: 441.62

Compound Purity: 96.48

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: 5-HT Receptor;Adrenergic Receptor;Dopamine Receptor

• Artikelnummer: MEXHY-15780S1-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-15780S1-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK