Buformin-d9 (hydrochloride)

Product Description: Buformin-d9 (hydrochloride) is the deuterium labeled Buformin. Buformin (1-Butylbiguanide), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. Buformin decreases hepatic gluconeogenesis and lowers blood glucose production in vivo. Buformin also has anti-cancer activities and is applied in cancer study (such as, cervical cancer and breast cancer, et al)[1].

Formula: C6H7D9ClN5

References: [1]Amanda B Parris, et al. Buformin Inhibits the Stemness of erbB-2-overexpressing Breast Cancer Cells and Premalignant Mammary Tissues of MMTV-erbB-2 Transgenic Mice. J Exp Clin Cancer Res/[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[3]Jing Li, et al. Buformin Suppresses Proliferation and Invasion via AMPK/S6 Pathway in Cervical Cancer and Synergizes With Paclitaxel. Cancer Biol Ther. 2018 Jun 3;19(6):507-517.

Molecular Weight: 202.73

Research Area: Cancer; Metabolic Disease

Solubility: 10 mM in DMSO

Target: AMPK;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B2099S-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B2099S-5
• Green Labware: Nein
• Verpackungseinheit: 5mg
• Mengeneinheit: STK