C6 Ceramide-d11

Product Description: C6 Ceramide-d11 is deuterated labeled C6 Ceramide (HY-19542). C6-ceramide, a ceramide pathway activator, shows activity against a variety of cancer cell lines. C6-ceramide can be used as an adjuvant for chemotherapeutic agents, to enhance anti-tumor effects[1][2].

Applications: Cancer-programmed cell death

Formula: C24H36D11NO3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Zhu Q, et, al. C6-ceramide synergistically potentiates the anti-tumor effects of histone deacetylase inhibitors via AKT dephosphorylation and α-tubulin hyperacetylation both in vitro and in vivo. Cell Death Dis. 2011 Jan 27;2(1):e117. /[3]Liu L, et, al. C6-ceramide treatment inhibits the proangiogenic activity of multiple myeloma exosomes via the miR-29b/Akt pathway. J Transl Med. 2020 Aug 3;18(1):298.

Molecular Weight: 408.70

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: Apoptosis;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-19542S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-19542S1-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK