Carprofen-13C,d3, CAS 2012598-34-2

Product Description: Carprofen-13C,d3 is the deuterium and 13C labeled Carprofen[1]. Carprofen is a nonsteroid anti-inflammatory agent, acts as a multi-target FAAH/COX inhibitor, with IC50s of 3.9 μM, 22.3 μM and 78.6 μM for COX-2, COX-1 and FAAH, respectively[2][3][4].

Applications: COVID-19-immunoregulation

Formula: C14 13CH9D3ClNO2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Favia AD, et al. Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. J Med Chem. 2012 Oct 25;55(20):8807-26./[3]Waldherr K, et al. In vitro cytoprotective effects of acetylsalicylic acid, carprofen, meloxicam, or robenacoxib against apoptosis induced by sodium nitroprusside in canine cruciate ligament cells. Am J Vet Res. 2012 Nov73(11):1752-8./[4]Sessions JK, et al. In vivo effects of carprofen, deracoxib, and etodolac on prostanoid production in blood, gastric mucosa, and synovial fluid in dogs with chronic osteoarthritis. Am J Vet Res. 2005 May66(5):812-7.

CAS Number: 2012598-34-2

Molecular Weight: 277.73

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Autophagy;COX;Endogenous Metabolite;FAAH

• Artikelnummer: MEXHY-B1227S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1227S1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK