Cerivastatin-d3 (sodium), CAS 916314-45-9

Product Description: Cerivastatin-d3 sodium is deuterated labeled Cerivastatin sodium (HY-109523). Cerivastatin sodium is a synthetic lipid-lowering agent and a highly potent, well-tolerated and orally active HMG-CoA reductase inhibitor, with a Ki of 1.3 nM/L. Cerivastatin sodium reduces low-density lipoprotein cholesterol levels. Cerivastatin sodium also inhibits proliferation and invasiveness of MDA-MB-231 cells, mainly by RhoA inhibition, and has anti-cancer effect[1][2].

Applications: Cancer-programmed cell death

Formula: C26H30D3FNNaO5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Denoyelle C, et al. Cerivastatin, an inhibitor of HMG-CoA reductase, inhibits the signaling pathways involved in the invasiveness and metastatic properties of highly invasive breast cancer cell lines: an in vitro study. Carcinogenesis. 2001 Aug;22(8):1139-48./[3]Stein E, et al. Cerivastatin, a New Potent Synthetic HMG Co-A Reductase Inhibitor: Effect of 0.2 mg Daily in Subjects With Primary Hypercholesterolemia. J Cardiovasc Pharmacol Ther. 1997 Jan;2(1):7-16./[4]Furberg CD, et al. Withdrawal of cerivastatin from the world market. Curr Control Trials Cardiovasc Med. 2001;2(5):205-207.

CAS Number: 916314-45-9

Molecular Weight: 484.55

Research Area: Cancer; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Ferroptosis;HMG-CoA Reductase (HMGCR);Isotope-Labeled Compounds

• Artikelnummer: MEXHY-109523S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-109523S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK