Chlorotrianisene-d9, CAS 1276197-26-2

Product Description: Chlorotrianisene-d9 is the deuterium labeled Chlorotrianisene. Chlorotrianisene is a long-acting non-steroidal estrogen and an orally active estrogen receptor modulator. Chlorotrianisene exhibits antiestrogenic activity. Chlorotrianisene potently inhibits the enzyme COX-1 and inhibits platelet aggregation in whole blood[1][2][3].

Formula: C23H12D9ClO3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Ruenitz PC, et al. Estrogenic tamoxifen derivatives: categorization of intrinsic estrogenicity in MCF-7 cells. J Steroid Biochem Mol Biol. 1997 Nov-Dec;63(4-6):203-9./[3]Lounkine E, et al. Large-scale prediction and testing of drug activity on side-effect targets. Nature. 2012 Jun 10;486(7403):361-7./[4]Kupfer D, et al. Inactivation of the uterine estrogen receptor binding of estradiol during P-450 catalyzed metabolism of chlorotrianisene (TACE). Speculation that TACE antiestrogenic activity involves covalent binding to the estrogen receptor. FEBS Lett. 1990 Feb 12;261(1):59-62.

CAS Number: 1276197-26-2

Molecular Weight: 389.92

Research Area: Endocrinology; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: COX;Estrogen Receptor/ERR;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B2158S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B2158S-1
• Green Labware: Nein
• Verpackungseinheit: 1mg
• Mengeneinheit: STK