Cholesterol-18O, CAS 59613-51-3

Cholesterol-18O, CAS 59613-51-3
Artikelnummer
MEXHY-N0322S8-5
Verpackungseinheit
5mg
Hersteller
MedChemExpress

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Product Description: Cholesterol-18O is the deuterium labeled Cholesterol. Cholesterol is the major sterol in mammals. It is making up 20-25% of structural component of the plasma membrane. Plasma membranes are highly permeable to water but relatively impermeable to ions and protons. Cholesterol plays an important role in determining the fluidity and permeability characteristics of the membrane as well as the function of both the transporters and signaling proteins[1][2]. Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist[3][4].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C27H46 18O

References: [4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[1]Casaburi I, et al. Cholesterol as an Endogenous ERRα Agonist: A New Perspective to Cancer Treatment. Front Endocrinol (Lausanne). 2018 Sep 11;9:525./[2]Dietschy JM, et al. Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal. J Lipid Res. 2004 Aug;45(8):1375-97./[3]Fukui K, et al. Effect of Cholesterol Reduction on Receptor Signaling in Neurons. J Biol Chem. 2015 Sep 14.

CAS Number: 59613-51-3

Molecular Weight: 388.65

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Estrogen Receptor/ERR;Isotope-Labeled Compounds
Mehr Informationen
Artikelnummer MEXHY-N0322S8-5
Hersteller MedChemExpress
Hersteller Artikelnummer HY-N0322S8-5
Green Labware Nein
Verpackungseinheit 5mg
Mengeneinheit STK
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