Clindamycin-13C,d3, CAS 2140264-63-5

Product Description: Clindamycin-13C,d3 is the 13C- and deuterium labeled Clindamycin. Clindamycin is an orally active and broad-spectrum bacteriostatic lincosamide antibiotic. Clindamycin can inhibit bacterial protein synthesis, possessing the ability to suppress the expression of virulence factors in Staphylococcus aureus at sub-inhibitory concentrations (sub-MICs). Clindamycin resistance results from enzymatic methylation of the antibiotic binding site in the 50S ribosomal subunit (23S rRNA). Clindamycin decreases the production of Panton-Valentine leucocidin (PVL), toxic-shock-staphylococcal toxin (TSST-1) or alpha-haemolysin (Hla). Clindamycin also can be used for researching malaria[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C17 13CH30D3ClN2O5S

References: [1]Hodille E, et al. Clindamycin suppresses virulence expression in inducible clindamycin-resistant Staphylococcus aureus strains. Ann Clin Microbiol Antimicrob. 2018 Oct 20;17(1):38./[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-223.

CAS Number: 2140264-63-5

Molecular Weight: 428.99

Compound Purity: 99.0

Research Area: Infection

Solubility: 10 mM in DMSO

Target: Antibiotic;Bacterial;Isotope-Labeled Compounds;Parasite

• Artikelnummer: MEXHY-B1455S1-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1455S1-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK