Debutyldronedarone-d7 (hydrochloride)

Product Description: Debutyldronedarone-d7 hydrochloride is deuterated labeled Debutyldronedarone hydrochloride (HY-12753A). Debutyldronedarone (SR35021) hydrochloride, the main metabolite of Dronedarone, is a selective thyroid hormone receptor α1 (TRα1) inhibitor. Debutyldronedarone hydrochloride inhibits T3 binding to TRα1 and TRβ1 by 77% and 25%, respectively. Debutyldronedarone hydrochloride can be used for the research of arrhythmic[1].

Applications: Neuroscience-Neuromodulation

Formula: C27H30D7ClN2O5S

References: [1]Van Beeren HC, et al. Dronerarone acts as a selective inhibitor of 3,5,3'-triiodothyronine binding to thyroid hormone receptor-alpha1: in vitro and in vivo evidence. Endocrinology. 2003 Feb;144(2):552-8./[2]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 544.15

Research Area: Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Isotope-Labeled Compounds;Thyroid Hormone Receptor

• Artikelnummer: MEXHY-12753AS-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-12753AS-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK