Dorzolamide-d3 (hydrochloride)

Product Description: Dorzolamide-d3 hydrochloride is deuterated labeled Dorzolamide hydrochloride (HY-B0109A). Dorzolamide (L671152) hydrochloride is a potent carbonic anhydrase II inhibitor, with IC50 values of 0.18 nM and 600 nM for red blood cell CA-II and CA-I respectively. Dorzolamide possesses anti-tumor activity[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C10H14D3ClN2O4S3

References: [1]Belal M Ali, et al. Dorzolamide synergizes the antitumor activity of mitomycin C against Ehrlich's carcinoma grown in mice: role of thioredoxin-interacting protein. Naunyn Schmiedebergs Arch Pharmacol. 2015 Dec;388(12):1271-82./[2]J Biollaz, et al. Whole-blood pharmacokinetics and metabolic effects of the topical carbonic anhydrase inhibitor dorzolamide. Eur J Clin Pharmacol. 1995;47(5):455-60./[3]Sangly P Srinivas, et al. Inhibition of carbonic anhydrase activity in cultured bovine corneal endothelial cells by dorzolamide. Invest Ophthalmol Vis Sci. 2002 Oct;43(10):3273-8./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 363.92

Research Area: others

Solubility: 10 mM in DMSO

Target: Carbonic Anhydrase;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0109AS-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0109AS-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK