Fexofenadine-d3-1

Product Description: Fexofenadine-d3-1 fumarate is deuterated labeled Fexofenadine (HY-B0801). Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research[1][2][3].

Applications: COVID-19-immunoregulation

Formula: C32H36D3NO4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Watanabe N, et al. The effects of fexofenadine on eosinophilia and systemic anaphylaxis in mice infected with Trichinella spiralis. Int Immunopharmacol. 2004 Mar;4(3):367-75./[3]Park IH, et al. Histamine Promotes the Release of Interleukin-6 via the H1R/p38 and NF-κB Pathways in Nasal Fibroblasts. Allergy Asthma Immunol Res. 2014 Nov;6(6):567-72./[4]Ming X, et al. Vectorial transport of fexofenadine across Caco-2 cells: involvement of apical uptake and basolateral efflux transporters. Mol Pharm. 2011 Oct 3;8(5):1677-86.

Molecular Weight: 504.67

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Histamine Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B0801S4-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0801S4-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK