Flufenamic acid-13C6, CAS 1325559-30-5

Product Description: Flufenamic acid-13C6 is the 13C6 labeled Flufenamic acid. Flufenamic acid is a non-steroidal anti-inflammatory agent, inhibits cyclooxygenase (COX), activates AMPK, and also modulates ion channels, blocking chloride channels and L-type Ca2+ channels, modulating non-selective cation channels (NSC), activating K+ channels. Flufenamic acid binds to the central pocket of TEAD2 YBD and inhibits both TEAD function and TEAD-YAP-dependent processes, such as cell migration and proliferation.

Applications: COVID-19-immunoregulation

Formula: C8 13C6H10F3NO2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Guinamard R, et al. Flufenamic acid as an ion channel modulator. Pharmacol Ther. 2013 May;138(2):272-84./[3]Pobbati AV, et al. Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy. Structure. 2015;23(11):2076-2086./[4]Pongkorpsakol P, et al. Cellular mechanisms underlying the inhibitory effect of flufenamic acid on chloride secretion in human intestinal epithelial cells. J Pharmacol Sci. 2017 Jun;134(2):93-100./[5]Pongkorpsakol P, et al. Flufenamic acid protects against intestinal fluid secretion and barrier leakage in a mouse model of Vibrio cholerae infection through NF-κB inhibition and AMPK activation. Eur J Pharmacol. 2017 Mar 5;798:94-104.

CAS Number: 1325559-30-5

Molecular Weight: 287.19

Compound Purity: 99.5

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: AMPK;Calcium Channel;Chloride Channel;COX;Isotope-Labeled Compounds;Parasite;Potassium Channel

• Artikelnummer: MEXHY-B1221S1-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1221S1-1
• Green Labware: Nein
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK