Frovatriptan-d3 (succinate)

Product Description: Frovatriptan-d3 (succinate) is deuterium labeled Frovatriptan (succinate). Frovatriptan succinate ((R)-Frovatriptan succinate) is a potent, high affinity, selective and orally active 5-HT1B (pK50 of 8.2) and 5-HT1D receptor agonist. Frovatriptan succinate exhibits >10-fold selectivity for 5-HT1B and 5-HT1D over 5-HT1A, 5-HT1F, and 5-HT7 and >1000-fold selectivity over other 5-HT, dopamine, histamine H1, and α1-adrenoceptor. Frovatriptan succinate has the potential for migraine research[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C18H20D3N3O5

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Comer MB. Et al. Pharmacology of the selective 5-HT(1B/1D) agonist frovatriptan. Headache. 2002 Apr;42 Suppl 2:S47-53./[3]Kelman L. Review of frovatriptan in the treatment of migraine. Neuropsychiatr Dis Treat. 2008 Feb;4(1):49-54.

Molecular Weight: 364.41

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: 5-HT Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B1658BS-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1658BS-5
• Green Labware: Nein
• Verpackungseinheit: 5mg
• Mengeneinheit: STK