Hydrochlorothiazide-15N2,13C,d2, CAS 2140316-81-8

Product Description: Hydrochlorothiazide-15N2,13C,d2 is 15N and deuterated labeled Hydrochlorothiazide (HY-B0252). Hydrochlorothiazide (HCTZ), an orally active diuretic agent of the thiazide class, inhibits transforming TGF-β/Smad signaling pathway. Hydrochlorothiazide has direct vascular relaxant effects via opening of the calcium-activated potassium (KCA) channel. Hydrochlorothiazide improves cardiac function, reduces fibrosis and has antihypertensive effect[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C6 13CH6D2ClN 15N2O4S2

References: [1]Magdy M Abdelquader, et al. Inhibition of Co-Crystallization of Olmesartan Medoxomil and Hydrochlorothiazide for Enhanced Dissolution Rate in Their Fixed Dose Combination. AAPS PharmSciTech. 2018 Dec 17;20(1):3./[2]Duarte, J.D. and R.M. Cooper-DeHoff, Mechanisms for blood pressure lowering and metabolic effects of thiazide and thiazide-like diuretics. Expert Rev Cardiovasc Ther, 2010. 8(6): p. 793-802./[3]Jinghong Luo, et al. Hydrochlorothiazide modulates ischemic heart failure-induced cardiac remodeling via inhibiting angiotensin II type 1 receptor pathway in rats. Cardiovasc Ther. 2017 Apr;35(2)./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

CAS Number: 2140316-81-8

Molecular Weight: 302.73

Research Area: Cancer; Metabolic Disease; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Isotope-Labeled Compounds;Potassium Channel;TGF-beta/Smad

• Artikelnummer: MEXHY-B0252S3-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0252S3-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK