JH-RE-06-d6

Product Description: JH-RE-06-d6 is deuterium labele JH-RE-06. JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Ki=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy[1].

Formula: C20H10D6Cl3N3O4

References: [1]Wojtaszek JL, et al. A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. Cell. 2019;178(1):152-159.e11.

Molecular Weight: 474.75

Research Area: Cancer

Target: DNA/RNA Synthesis

• Artikelnummer: MEXHY-126214S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-126214S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK