Lamivudine-15N,d2

Product Description: Lamivudine-15N,d2 is 15N and deuterated labeled Lamivudine (HY-B0250). Lamivudine (BCH-189) is an orally active nucleoside reverse transcriptase inhibitor (NRTI). Lamivudine can inhibit HIV reverse transcriptase 1/2 and also the reverse transcriptase of hepatitis B virus. Lamivudine salicylate can penetrate the CNS[1][2].

Applications: COVID-19-anti-virus

Formula: C8H10D2ClN2 15NO3S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Colledge D, et al. Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology. 1997 Jul;26(1):216-25. /[3]Olaniyan LW, et al. Lamivudine-Induced Liver Injury. Open Access Maced J Med Sci. 2015 Dec 15;3(4):545-50. /[4]Mdanda S, et al. Zidovudine and Lamivudine as Potential Agents to Combat HIV-Associated Neurocognitive Disorder. Assay Drug Dev Technol. 2019 Oct;17(7):322-329. 

Molecular Weight: 268.72

Research Area: Cancer; Infection

Solubility: 10 mM in DMSO

Target: HBV;HIV;Isotope-Labeled Compounds;Reverse Transcriptase

• Artikelnummer: MEXHY-B0250S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0250S-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK