Liothyronine-d3

Product Description: Liothyronine-d3 is deuterated labeled Liothyronine (HY-A0070A). Liothyronine is an active form of thyroid hormone. Liothyronine is a potent thyroid hormone receptors TRα and TRβ agonist with Kis of 2.33 nM for hTRα and hTRβ, respectively[1][2][3].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C15H9D3I3NO4

References: [1]Hiroaki Shiohara, et al. Discovery of novel indane derivatives as liver-selective thyroid hormone receptor β (TRβ) agonists for the treatment of dyslipidemia. Bioorg Med Chem. 2012 Jun 1;20(11):3622-34./[2]Lin KH, et al. Stimulation of proliferation by 3,3',5-triiodo-L-thyronine in poorly differentiated human hepatocarcinoma cells overexpressing beta 1 thyroid hormone receptor. Cancer Lett. 1994 Oct 14;85(2):189-94./[3]Bhat MK, et al. Conformational changes of human beta 1 thyroid hormone receptor induced by binding of 3,3',5-triiodo-L-thyronine. Biochem Biophys Res Commun. 1993 Aug 31;195(1):385-92./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 653.99

Research Area: Cancer; Endocrinology

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Isotope-Labeled Compounds;Thyroid Hormone Receptor

• Artikelnummer: MEXHY-A0070AS3-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-A0070AS3-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK