Mecamylamine (hydrochloride)-13C4,15N

Product Description: Mecamylamine (hydrochloride)-13C4,15N is the 13C-labeled and 15N-labeled Mecamylamine hydrochloride. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist that can treat various neuropsychiatric disorders. Mecamylamine hydrochloride is originally used as a ganglionic blocker in treating hypertension. Mecamylamine hydrochloride can easily crosses the blood-brain barrier[1][2].

Formula: C7 13C4H10Cl 15N

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. /[2]Ostroumov K, et al. Modeling study of mecamylamine block of muscle type acetylcholine receptors. Eur Biophys J. 2008 Apr;37(4):393-402./[3]Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401./[4]Bacher I, et al. Mecamylamine - a nicotinic acetylcholine receptor antagonist with potential for the treatment of neuropsychiatric disorders. Expert Opin Pharmacother. 2009 Nov;10(16):2709-21.

Molecular Weight: 196.62

Research Area: Neurological Disease

Solubility: 10 mM in DMSO

Target: Isotope-Labeled Compounds;nAChR

• Artikelnummer: MEXHY-B1395S1-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1395S1-5
• Green Labware: Nein
• Verpackungseinheit: 5mg
• Mengeneinheit: STK