Mequitazine-d8 (hydrobromide)

Product Description: Mequitazine-d8 hydrobromide is deuterated labeled Mequitazine (HY-B2168). Mequitazine is a potent, and long-acting histamine H1 antagonist.

Applications: Metabolism-protein/nucleotide metabolism

Formula: C20H15D8BrN2S

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Gonnot V, et al. Expedient synthesis of mequitazine an antihistaminic drug by palladium catalyzed allylic alkylation of sodium phenothiazinate. Chem Pharm Bull (Tokyo). 2009 Nov;57(11):1300-2./[3]El-Nakeeb MA, et a. In vitro antibacterial activity of some antihistaminics belonging to different groups against multi-drug resistant clinical isolates. Braz J Microbiol. 2011 Jul;42(3):980-91./[4]Martinez-Mir I, et al. Antihistaminic and anticholinergic activities of mequitazine in comparison with clemizole. J Pharm Pharmacol. 1988 Sep;40(9):655-6./[5]Satake N, et al. Possible mechanisms of vasoinhibitory effects of mequitazine, an antiallergic agent, on the contractions of isolated rat aorta induced by K+, phenylephrine, 5-hydroxytryptamine, and Ca2+. J Cardiovasc Pharmacol. 1994 Apr;23(4):669-73.

Molecular Weight: 411.43

Research Area: Endocrinology; Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Histamine Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B2168S-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B2168S-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK