Mifepristone-d6, CAS 1228097-18-4

Product Description: Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay[1].

Applications: Metabolism-sugar/lipid metabolism

Formula: C29H29D6NO2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Jurado R, et al. NSC 119875 cytotoxicity is increased by mifepristone in cervical carcinoma: an in vitro and in vivo study. Oncol Rep. 2009 Nov;22(5):1237-45./[3]Sharrett-Field L, et al. Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo. Alcohol Clin Exp Res. 2013 Aug;37(8):1417-23./[4]Jiang W, et al. New progesterone receptor antagonists: phosphorus-containing 11beta-aryl-substituted steroids. Bioorg Med Chem. 2006 Oct 1;14(19):6726-32./[5]Yuehua You, et al. Progesterone Promotes Endothelial Nitric Oxide Synthase Expression Through Enhancing Nuclear Progesterone receptor-SP1 Formation. Am J Physiol Heart Circ Physiol. 2020 Jul 3.

CAS Number: 1228097-18-4

Molecular Weight: 435.63

Research Area: Cancer; Endocrinology

Solubility: 10 mM in DMSO

Target: Autophagy;Endogenous Metabolite;Glucocorticoid Receptor;Isotope-Labeled Compounds;NO Synthase;Progesterone Receptor

• Artikelnummer: MEXHY-13683S2-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-13683S2-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK