Moexipril-d3

Product Description: Moexipril-d3 is deuterated labeled Moexipril (HY-117281). Moexipril is an orally active inhibitor of angiotensin-converting enzyme (ACE), and becomes effective by being hydrolyzed to moexiprila hydrochloride. Moexipril exhibits antihypertensive and neuroprotective effects[1]-[4].

Applications: Neuroscience-Neurodegeneration

Formula: C27H31D3N2O7

References: [1]Chrysant, S.G. and G.S. Chrysant, Pharmacological and clinical profile of moexipril: a concise review. J Clin Pharmacol, 2004. 44(8): p. 827-36./[2]Friehe H, et al. Pharmacological and toxicological studies of the new angiotensin converting enzyme inhibitor moexipril hydrochloride. Arzneimittelforschung. 1997 Feb. 47(2):132-44./[3]Edling O, et al. Moexipril, a new angiotensin-converting enzyme (ACE) inhibitor: pharmacological characterization and comparison with enalapril. J Pharmacol Exp Ther. 1995 Nov;275(2):854-63./[4]Ravati A, et al. Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. Eur J Pharmacol. 1999 May 28;373(1):21-33./[5]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 501.59

Research Area: Neurological Disease; Cardiovascular Disease

Solubility: 10 mM in DMSO

Target: Angiotensin-converting Enzyme (ACE);Apoptosis;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-117281S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-117281S1-0
• Verpackungseinheit: Get quote
• Mengeneinheit: STK