MPP+-d3(iodide), CAS 207556-07-8

Product Description: MPP+-d3 (iodide) is deuterium labeled MPP+ (iodide). MPP+ iodide, a toxic metabolite of the neurotoxin MPTP, causes symptom of Parkinson's disease in animal models by selectively destroying dopaminergic neurons in substantia nigra. MPP+ iodide is taken up by the dopamine transporter into dopaminergic neurons where it exerts its neurotoxic action on mitochondria by affecting complex I of the respiratory chain. MPP+ iodide is also a high affinity substrate for the serotonin transporter (SERT)[1][2].

Applications: Neuroscience-Neuromodulation

Formula: C12H9D3IN

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Charlton CG. 1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) serves as methyl donor for dopamine: a possible mechanism of action. J Geriatr Psychiatry Neurol. 1992;5(2):114-118./[3]Martí Y, et al. Methyl-4-phenylpyridinium (MPP+) differentially affects monoamine release and re-uptake in murine embryonic stem cell-derived dopaminergic and serotonergic neurons. Mol Cell Neurosci. 2017;83:37-45./[4]Zhao M, et al. Mitochondrial calcium dysfunction contributes to autophagic cell death induced by MPP+ via AMPK pathway. Biochem Biophys Res Commun. 2019;509(2):390-394.

CAS Number: 207556-07-8

Molecular Weight: 300.15

Compound Purity: 99.60

Research Area: Neurological Disease

Solubility: DMSO : 100 mg/mL (ultrasonic)

Target: Mitochondrial Metabolism

• Artikelnummer: MEXHY-W008719S-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-W008719S-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK