N-Desmethylclozapine-d8 (hydrochloride), CAS 2705402-91-9

Product Description: N-Desmethylclozapine-d8 (hydrochloride) is the deuterium labeled N-Desmethylclozapine hydrochloride. N-Desmethylclozapine hydrochloride is a major active metabolite of the atypical antipsychotic agent Clozapine. N-Desmethylclozapine hydrochloride is a potent, allosteric and partial M1 receptors agonist (EC50=115 nM) and is able to potentiate hippocampal N-methyl-d-aspartate (NMDA) receptor currents through M1 receptor activation. N-Desmethylclozapine hydrochloride is also a δ-opioid agonist[1][2][3].

Applications: COVID-19-anti-virus

Formula: C17H10D8Cl2N4

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Li Z, et al. N-desmethylclozapine, a major metabolite of clozapine, increases cortical acetylcholine and dopamine release in vivo via stimulation of M1 muscarinic receptors. Neuropsychopharmacology. 2005 Nov;30(11):1986-95./[3]Odagaki Y, et al. Comparative analysis of pharmacological properties of xanomeline and N-desmethylclozapine in rat brain membranes. J Psychopharmacol. 2016 Sep;30(9):896-912.

CAS Number: 2705402-91-9

Molecular Weight: 357.31

Compound Purity: 99.74

Research Area: Infection

Solubility: 10 mM in DMSO

Target: Drug Metabolite;mAChR;Opioid Receptor;Virus Protease

• Artikelnummer: MEXHY-G0021S1-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-G0021S1-5
• Green Labware: Nein
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK