Nefazodone-d6 (dihydrochloride)

Product Description: Nefazodone-d6 (dihydrochloride) is deuterium labeled Nefazodone (hydrochloride). Nefazodone hydrochloride (BMY-13754) is a potent and selective 5HT2A (Ki=5.8 nM) antagonist with moderate inhibition of 5-HT and noradrenaline uptake (IC50 of 290 and 300 nM, respectively). Nefazodone hydrochloride is a phenylpiperazine antidepressant with less alpha-adrenergic blocking activity[1][2].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C25H28D6Cl3N5O2

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Ellingrod VL, et al. Nefazodone: a new antidepressant. Am J Health Syst Pharm. 1995;52(24):2799-2812./[3]Pullar IA, et al. LY367265, an inhibitor of the 5-hydroxytryptamine transporter and 5-hydroxytryptamine(2A) receptor antagonist: a comparison with the antidepressant, nefazodone. Eur J Pharmacol. 2000;407(1-2):39-46.

Molecular Weight: 548.97

Research Area: Neurological Disease; Endocrinology

Solubility: 10 mM in DMSO

Target: 5-HT Receptor;Adrenergic Receptor;Isotope-Labeled Compounds

• Artikelnummer: MEXHY-B1396S1-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B1396S1-1
• Green Labware: Nein
• Verpackungseinheit: 1mg
• Mengeneinheit: STK