Nintedanib-d3, CAS 1624587-84-3

Product Description: Nintedanib-d3 is the deuterium labeled Nintedanib. Nintedanib (BIBF 1120) is a potent triple angiokinase inhibitor for VEGFR1/2/3, FGFR1/2/3 and PDGFRα/β with IC50s of 34 nM/13 nM/13 nM, 69 nM/37 nM/108 nM and 59 nM/65 nM, respectively.

Formula: C31H30D3N5O4

References: [1]Roth GJ, et al. Design, synthesis, and evaluation of indolinones as triple angiokinase inhibitors and the discovery of a highly specific 6-methoxycarbonyl-substituted indolinone (BIBF 1120). J Med Chem, 2009, 52(14), 4466-4480./[2]Hilberg F, et al. BIBF 1120: triple angiokinase inhibitor with sustained receptor blockade and good antitumor efficacy. Cancer Res, 2008, 68(12), 4774-4782./[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

CAS Number: 1624587-84-3

Molecular Weight: 542.64

Research Area: Cancer

Solubility: 10 mM in DMSO

Target: FGFR;PDGFR;VEGFR

• Artikelnummer: MEXHY-50904S-1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-50904S-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK