Olsalazine-d3

Product Description: Olsalazine-d3 is deuterated labeled Olsalazine (HY-B0174A). Olsalazine is a potent inhibitor of macrophages chemotaxis to LTB4 with an IC50 value of 0.39 mM, also reduces the synthesis of 5-hydroxyeicosatetraenoic acid (5-HETE), 11-HETE, 12-HETE, and 15-HETE in polymorphonuclear leukocyte (PMNL) and mononuclear cells (MNL). Olsalazine can be used for researching ulcerative colitis. Anti-inflammatory activity[1][2].

Applications: COVID-19-immunoregulation

Formula: C14H7D3N2O6

References: [1]Nielsen, O.H., H.W. Verspaget, and J. Elmgreen, Inhibition of intestinal macrophage chemotaxis to leukotriene B4 by sulphasalazine, olsalazine, and 5-aminosalicylic acid. Aliment Pharmacol Ther, 1988. 2(3): p. 203-11./[2]Horn H, et al. Modulation of arachidonic acid metabolism by olsalazine and other aminosalicylates in leukocytes. Scand J Gastroenterol. 1991 Aug;26(8):867-79./[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 305.26

Research Area: Inflammation/Immunology

Solubility: 10 mM in DMSO

Target: Antibiotic;Isotope-Labeled Compounds;Leukotriene Receptor

• Artikelnummer: MEXHY-B0174AS1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0174AS1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK