Omeprazole-d3 (sodium)

Product Description: Omeprazole-d3 sodium is deuterated labeled Omeprazole (HY-B0113). Omeprazole (H 16868), a proton pump inhibitor (PPI), is available for treatment of acid-related gastrointestinal disorders. Omeprazole shows competitive inhibition of CYP2C19 activity with a Ki of 2 to 6 μM[1]. Omeprazole also inhibits growth of Gram-positive and Gram-negative bacteria[2].Omeprazole is a potent brain penetrant neutral sphingomyelinase (N-SMase) inhibitor (exosome inhibitor)[3].

Applications: Metabolism-sugar/lipid metabolism

Formula: C17H15D3N3NaO3S

References: [1]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330./[2]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7./[3]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50./[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.

Molecular Weight: 370.42

Research Area: Cancer; Infection; Metabolic Disease

Solubility: 10 mM in DMSO

Target: Autophagy;Bacterial;Isotope-Labeled Compounds;Phospholipase;Proton Pump

• Artikelnummer: MEXHY-B0113S4-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0113S4-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK