Orotic acid-13C,15N2 (monohydrate), CAS 1346602-15-0

Product Description: Orotic acid-13C,15N2 (monohydrate) is the 13C and 15N labeled Orotic acid[1]. Orotic acid (6-Carboxyuracil), a precursor in biosynthesis of pyrimidine nucleotides and RNA, is released from the mitochondrial dihydroorotate dehydrogenase (DHODH) for conversion to UMP by the cytoplasmic UMP synthase enzyme. Orotic acid is a marker for measurement in routine newborn screening for urea cycle disorders. Orotic acid can induce hepatic steatosis and hepatomegaly in rats[2][3][4].

Applications: Metabolism-protein/nucleotide metabolism

Formula: C4 13CH6 15N2O5

References: [3]Staretz-Chacham O, et, al. The role of orotic acid measurement in routine newborn screening for urea cycle disorders. J Inherit Metab Dis. 2020 Nov 15./[4]Durschlag RP, et, al. Orotic acid-induced metabolic changes in the rat. J Nutr. 1980 Apr110(4):816-21./[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216./[2]Löffler M, et, al. Orotate (orotic acid): An essential and versatile molecule. Nucleosides Nucleotides Nucleic Acids.

CAS Number: 1346602-15-0

Molecular Weight: 177.09

Research Area: Metabolic Disease

Solubility: 10 mM in DMSO

Target: Endogenous Metabolite;Nucleoside Antimetabolite/Analog

• Artikelnummer: MEXHY-N0157S1-0
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-N0157S1-0
• Green Labware: Nein
• Verpackungseinheit: Get quote
• Mengeneinheit: STK