Oxaprozin-d5

Product Description: Oxaprozin-d5 is deuterium labeled Oxaprozin. Oxaprozin is an inhibitor of both COX-1 and COX-2 with IC50s of 2.2 μM and 36 μM for human platelet COX-1 and IL-1-stimulated human synovial cell COX-2, respectively. Oxaprozin also inhibits the activation of NF-κB.

Applications: COVID-19-immunoregulation

Formula: C18H10D5NO3

References: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216./[2]Montecucco F, et al. Oxaprozin-induced apoptosis on CD40 ligand-treated human primary monocytes is associated with the modulation of defined intracellular pathways. J Biomed Biotechnol. 2009;2009:478785./[3]Ottonello L, et al. Delayed apoptosis of human monocytes exposed to immune complexes is reversed byoxaprozin: role of the Akt/IkappaB kinase/nuclear factor kappaB pathway. Br J Pharmacol. 2009 May;157(2):294-306.

Molecular Weight: 298.35

Research Area: Inflammation/Immunology; Cancer

Solubility: 10 mM in DMSO

Target: COX;Isotope-Labeled Compounds;NF-κB

• Artikelnummer: MEXHY-B0808S1-5
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-B0808S1-5
• Green Labware: Nein
• Verpackungseinheit: 5mg
• Mengeneinheit: STK